Systems genetics approaches for understanding complex traits with relevance for human disease.
Elife
; 122023 11 14.
Article
em En
| MEDLINE
| ID: mdl-37962168
ABSTRACT
Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metabolite levels, to understand molecular and physiological phenotypes linking discrete DNA sequence variation to complex clinical and physiological traits. The primary purpose of this review is to describe some of the resources and tools of systems genetics in humans and rodent models, so that researchers in many areas of biology and medicine can make use of the data.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Herança Multifatorial
/
Biologia de Sistemas
Limite:
Humans
Idioma:
En
Revista:
Elife
Ano de publicação:
2023
Tipo de documento:
Article