Engineering U1-Based Tetracycline-Inducible Riboswitches to Control Gene Expression in Mammals.

Rovira, Eric; Moreno, Beatriz; Razquin, Nerea; Blázquez, Lorea; Hernández-Alcoceba, Ruben; Fortes, Puri; Pastor, Fernando

Rovira, Eric; Moreno, Beatriz; Razquin, Nerea; Blázquez, Lorea; Hernández-Alcoceba, Ruben; Fortes, Puri; Pastor, Fernando.

Afiliação

Rovira E; Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona 31008, Spain.
Moreno B; Department of Molecular Therapy, Aptamer Unit, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona 31008, Spain.
Razquin N; Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona 31008, Spain.
Blázquez L; Department of Neurosciences, Biodonostia Health Research Institute, 20014 San Sebastián, Spain.
Hernández-Alcoceba R; CIBERNED, ISCIII (CIBER, Carlos III Institute, Spanish Ministry of Sciences and Innovation), 28031 Madrid, Spain.
Fortes P; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain.
Pastor F; Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona 31008, Spain.

ACS Nano ; 17(23): 23331-23346, 2023 Dec 12.

Article em En | MEDLINE | ID: mdl-37971502

Assuntos

Riboswitch; Animais; Camundongos; Riboswitch/genética; Ribonucleoproteína Nuclear Pequena U1/genética; Tetraciclina/farmacologia; Antibacterianos; Mamíferos/genética; Expressão Gênica

Palavras-chave

SELEX; U1 snRNP; U1i; aptamer; gene expression regulation; riboswitch; tetracycline

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Riboswitch Limite: Animals Idioma: En Revista: ACS Nano Ano de publicação: 2023 Tipo de documento: Article

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