Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange.

Cruite, Justin T; Nowak, Radoslaw P; Donovan, Katherine A; Ficarro, Scott B; Huang, Huang; Liu, Hu; Liu, Yingpeng; Marto, Jarrod A; Metivier, Rebecca J; Fischer, Eric S; Jones, Lyn H

Cruite, Justin T; Nowak, Radoslaw P; Donovan, Katherine A; Ficarro, Scott B; Huang, Huang; Liu, Hu; Liu, Yingpeng; Marto, Jarrod A; Metivier, Rebecca J; Fischer, Eric S; Jones, Lyn H.

Afiliação

Cruite JT; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Nowak RP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.
Donovan KA; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Ficarro SB; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.
Huang H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.
Liu H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Liu Y; Department of Cancer Biology, Department of Oncologic Pathology, Blais Proteomics Center, and Center for Emergent Drug Targets, Dana-Farber Cancer Institute, Boston Massachusetts 02215, United States.
Marto JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Metivier RJ; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Fischer ES; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.
Jones LH; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.

ACS Med Chem Lett ; 14(11): 1576-1581, 2023 Nov 09.

Article em En | MEDLINE | ID: mdl-37974938

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2023 Tipo de documento: Article