[Translated article] Infrapatellar fat pad resection effect on the osteoarthritis development: Experimental study in sheep.
Rev Esp Cir Ortop Traumatol
; 68(2): T134-T141, 2024.
Article
em En, Es
| MEDLINE
| ID: mdl-37992862
ABSTRACT
INTRODUCTION:
The fat of the synovial joints can be used to maintain the joint structure. Our objective is to analyse the evolution of joint degeneration in knees with and without adipose pack. MATERIAL ANDMETHODOLOGY:
In six sheep, the anterior cruciate ligament was sectioned in both knees, to cause osteoarthritis. In one group the fat pack was preserved and in another group it was completely removed. We performed a histological and molecular biology study analyzing the expression, in the synovial membrane, subchondral bone, cartilage, fat, meniscus, and synovial fluid, of RUNX2, PTHrP, cathepsin-K, and MCP1.RESULTS:
We did not find morphological differences. We found increased expression of RUNX2 in synovial membrane, PTHrP and Cathepsin K in synovial fluid in the group without fat, and increased expression of RUNX2 in the meniscus and MCP1 in synovial fluid in the group with fat.CONCLUSION:
Infrapatellar fat participates in the inflammatory process that accompanies osteoarthritis, since Hoffa fat pad resection alters pro-inflammatory markers, while the model with intact fat increases the pro-inflammatory marker MCP1 in synovial fluid.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
/
Es
Revista:
Rev Esp Cir Ortop Traumatol
Ano de publicação:
2024
Tipo de documento:
Article