Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2.
Mov Disord
; 39(1): 203-209, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38037516
ABSTRACT
BACKGROUND:
ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes.OBJECTIVE:
The aim was to investigate optic disc and retinal architecture in SCA2.METHODS:
We evaluated 14 patients with SCA2 and 26 controls who underwent intraocular pressure measurement, fundoscopy, and macular and peripapillary spectral domain optical coherence tomography (SD-OCT). We compared SD-OCT measurements in SCA2 and controls, and the frequency of glaucomatous changes among SCA2, controls, and 76 patients with other SCAs (types 1, 3, 6, and 7).RESULTS:
The macula, peripapillary retinal nerve fiber and inner plexiform layers were thinner in SCA2 than in controls. Increased cup-to-disc ratio was more frequent in SCA2 than in controls and other SCAs.CONCLUSIONS:
Ocular changes are part of SCA2 phenotype. Future studies should further investigate retinal and optic nerve architecture in this disorder.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disco Óptico
/
Macula Lutea
Limite:
Humans
Idioma:
En
Revista:
Mov Disord
Ano de publicação:
2024
Tipo de documento:
Article