Upregulated Tß4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice.

Hao, Menghao; Zhong, Ke; Bai, Xiaoqin; Wu, Shiyan; Li, Lu; He, Yumei; Wang, Zhiming; Sun, Xiaobin; Wang, Qiong; Guo, Yuanbiao; Sun, Yueshan; Wu, Liping

Hao, Menghao; Zhong, Ke; Bai, Xiaoqin; Wu, Shiyan; Li, Lu; He, Yumei; Wang, Zhiming; Sun, Xiaobin; Wang, Qiong; Guo, Yuanbiao; Sun, Yueshan; Wu, Liping.

Afiliação

Hao M; School of Medicine, Southwest Jiaotong University, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengd
Zhong K; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Bai X; Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Wu S; Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Li L; Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
He Y; North Sichuan Medical College, Nanchong, 637000, China.
Wang Z; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Sun X; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Wang Q; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Guo Y; Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Sun Y; Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China. Electronic address: sysnjsdx@163.com.
Wu L; Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China. Electronic address: wuliping@swjtu.edu.cn.

Exp Cell Res ; 434(1): 113871, 2024 01 01.

Article em En | MEDLINE | ID: mdl-38049080

Assuntos

Doenças Inflamatórias Intestinais; Timosina; Animais; Feminino; Humanos; Camundongos; Autofagia/efeitos dos fármacos; Linhagem Celular Tumoral; Colite/metabolismo; Colite/patologia; Colo/metabolismo; Colo/patologia; Doenças Inflamatórias Intestinais/metabolismo; Doenças Inflamatórias Intestinais/patologia; Camundongos Endogâmicos C57BL; Sirolimo/administração & dosagem; Timosina/genética; Timosina/metabolismo; Regulação para Cima

Palavras-chave

Autophagy; Inflammatory bowel disease; Intestinal epithelial cells; Mucin2; Mucus barrier; Thymosin ß4

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timosina / Doenças Inflamatórias Intestinais Limite: Animals / Female / Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google