The correlation of lymphocytes with disease progression of COVID-19.
Medicine (Baltimore)
; 102(48): e36244, 2023 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-38050270
ABSTRACT
The aim of this study is to evaluate the potential of lymphocytes as biomarkers to predict the decline of coronavirus disease 2019 (COVID-19). Lymphocytes were counted in 164 moderate COVID-19 patients in Shenzhen, China. Among the moderate infected patients, 12.2% (20/164) progressed to severe cases after admission. Compared with the stable patients, the counts of lymphocytes, both total T lymphocytes and CD4+ T lymphocytes, in the severe patients, were lower. The aggravation of moderate infected patients was significantly associated with lymphocyte count (hazard ratio [HR]â
=â
0.91; 95% confidence interval [CI] 0.84-0.99), total T lymphocyte count (HRâ
=â
0.91; 95% CI 0.84-0.99), and CD4+ T lymphocyte count (HRâ
=â
0.91; 95% CI 0.85-0.98). Total T lymphocytes and CD4+ T lymphocytes could be important biomarkers to evaluate the risk of aggravation for moderate infected COVID-19 patients. The patients with low percentages of total T lymphocytes and CD4+ T lymphocytes need more attention.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2023
Tipo de documento:
Article