Your browser doesn't support javascript.
loading
Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis.
Sharif, Nadim; Sharif, Nazmul; Khan, Afsana; Azpíroz, Irma Domínguez; Diaz, Raquel Martínez; Díez, Isabel De la Torre; Parvez, Anowar Khasru; Dey, Shuvra Kanti.
Afiliação
  • Sharif N; Department of Microbiology, Jahangirnagar University, Dhaka, Bangladesh.
  • Sharif N; Department of Mathematics, Rajshahi University of Engineering & Technology, Rajshahi, Bangladesh.
  • Khan A; Department of Statistics, Jahangirnagar University, Dhaka, Bangladesh.
  • Azpíroz ID; Universidad Europea del Atlántico, Santander, Spain.
  • Diaz RM; Universidad Internacional Iberoamericana, Arecibo, PR, United States.
  • Díez IT; Universidad de La Romana, La Romana, Dominican Republic.
  • Parvez AK; Universidad Europea del Atlántico, Santander, Spain.
  • Dey SK; Universidade Internacional do Cuanza, Cuito, Bié, Angola.
Front Immunol ; 14: 1289032, 2023.
Article em En | MEDLINE | ID: mdl-38077390
ABSTRACT

Introduction:

Rotavirus infection is a major cause of mortality among children under 5 years in Bangladesh. There is lack of integrated studies on rotavirus prevalence and genetic diversity during 1973 to 2023 in Bangladesh.

Methods:

This meta-analysis was conducted to determine the prevalence, genotypic diversity and seasonal distribution of rotavirus during pre-vaccination period in Bangladesh. This study included published articles on rotavirus A, rotavirus B and rotavirus C. We used Medline, Scopus and Google Scholar for published articles. Selected literatures were published between 1973 to 2023.

Results:

This study detected 12431 research articles published on rotavirus. Based on the inclusion criteria, 29 of 75 (30.2%) studies were selected. Molecular epidemiological data was taken from 29 articles, prevalence data from 29 articles, and clinical symptoms from 19 articles. The pooled prevalence of rotavirus was 30.1% (95% CI 22%-45%, p = 0.005). Rotavirus G1 (27.1%, 2228 of 8219) was the most prevalent followed by G2 (21.09%, 1733 of 8219), G4 (11.58%, 952 of 8219), G9 (9.37%, 770 of 8219), G12 (8.48%, 697 of 8219), and G3 (2.79%, 229 of 8219), respectively. Genotype P[8] (40.6%, 2548 of 6274) was the most prevalent followed by P[4] (12.4%, 777 of 6274) and P[6] (6.4%, 400 of 6274), respectively. Rotavirus G1P[8] (19%) was the most frequent followed by G2P [4] (9.4%), G12P[8] (7.2%), and G9P[8], respectively. Rotavirus infection had higher odds of occurrence during December and February (aOR 2.86, 95% CI 2.43-3.6, p = 0.001).

Discussion:

This is the first meta-analysis including all the studies on prevalence, molecular epidemiology, and genetic diversity of rotavirus from 1973 to 2023, pre-vaccination period in Bangladesh. This study will provide overall scenario of rotavirus genetic diversity and seasonality during pre-vaccination period and aids in policy making for rotavirus vaccination program in Bangladesh. This work will add valuable knowledge for vaccination against rotavirus and compare the data after starting vaccination in Bangladesh.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Rotavirus Tipo de estudo: Systematic_reviews Limite: Child / Child, preschool / Humans País/Região como assunto: Asia Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Rotavirus Tipo de estudo: Systematic_reviews Limite: Child / Child, preschool / Humans País/Região como assunto: Asia Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article