Intramolecular Ni-catalyzed reductive coupling enables enantiodivergent synthesis of linoxepin.
Chem Commun (Camb)
; 60(6): 694-697, 2024 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-38105647
ABSTRACT
A nickel-catalyzed reductive tandem cyclization of the elaborated ß-bromo acetal with a dibenzoxepin scaffold was invented to strategically construct the remaining two rings in linoxepin. The generated diasterodivergent intermediates could be easily converted to both enantiomers of this unique cyclolignan molecule via facile oxidations, thus realizing enantiodivergent total synthesis of linoxepin for the first time.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2024
Tipo de documento:
Article