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Associations of Vitamins and Related Cofactor Metabolites with Mammographic Breast Density in Premenopausal Women.
Matthew, Kayode A; Getz, Kayla R; Jeon, Myung Sik; Luo, Chongliang; Luo, Jingqin; Toriola, Adetunji T.
Afiliação
  • Matthew KA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Getz KR; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Jeon MS; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States; Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Division of Public Health Sciences, Department of Surgery, Washington University School of
  • Luo C; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States; Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Division of Public Health Sciences, Department of Surgery, Washington University School of
  • Luo J; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States; Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Division of Public Health Sciences, Department of Surgery, Washington University School of
  • Toriola AT; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States. Electronic address: a.toriola@wustl.edu.
J Nutr ; 154(2): 424-434, 2024 02.
Article em En | MEDLINE | ID: mdl-38122846
ABSTRACT

BACKGROUND:

Identifying biological drivers of mammographic breast density (MBD), a strong risk factor for breast cancer, could provide insight into breast cancer etiology and prevention. Studies on dietary factors and MBD have yielded conflicting results. There are, however, very limited data on the associations of dietary biomarkers and MBD.

OBJECTIVE:

We aimed to investigate the associations of vitamins and related cofactor metabolites with MBD in premenopausal women.

METHODS:

We measured 37 vitamins and related cofactor metabolites in fasting plasma samples of 705 premenopausal women recruited during their annual screening mammogram at the Washington University School of Medicine, St. Louis, MO. Volpara was used to assess volumetric percent density (VPD), dense volume (DV), and nondense volume (NDV). We estimated the least square means of VPD, DV, and NDV across quartiles of each metabolite, as well as the regression coefficient of a metabolite in continuous scale from multiple covariate-adjusted linear regression. We corrected for multiple testing using the Benjamini-Hochberg procedure to control the false discover rate (FDR) at a 5% level.

RESULTS:

Participants' mean VPD was 10.5%. Two vitamin A metabolites (ß-cryptoxanthin and carotene diol 2) were positively associated, and one vitamin E metabolite (γ-tocopherol) was inversely associated with VPD. The mean VPD increased across quartiles of ß-cryptoxanthin (Q1 = 7.2%, Q2 = 7.7%, Q3 = 8.4%%, Q4 = 9.2%; P-trend = 1.77E-05, FDR P value = 1.18E-03). There was a decrease in the mean VPD across quartiles of γ-tocopherol (Q1 = 9.4%, Q2 = 8.1%, Q3 = 8.0%, Q4 = 7.8%; P -trend = 4.01E-03, FDR P value = 0.04). Seven metabolites were associated with NDV 3 vitamin E (γ-CEHC glucuronide, δ-CEHC, and γ-tocopherol) and 1 vitamin C (gulonate) were positively associated, whereas 2 vitamin A (carotene diol 2 and ß-cryptoxanthin) and 1 vitamin C (threonate) were inversely associated with NDV. No metabolite was significantly associated with DV.

CONCLUSION:

We report novel associations of vitamins and related cofactor metabolites with MBD in premenopausal women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Densidade da Mama Limite: Female / Humans Idioma: En Revista: J Nutr Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Densidade da Mama Limite: Female / Humans Idioma: En Revista: J Nutr Ano de publicação: 2024 Tipo de documento: Article