Metastatic Squamous Cell Carcinoma of the Urinary Bladder: Urgent Call for New Therapies.
Urol Int
; 108(1): 1-8, 2024.
Article
em En
| MEDLINE
| ID: mdl-38128507
ABSTRACT
BACKGROUND:
Squamous cell carcinoma (SCC) of the urinary bladder is the most common non-urothelial variant histology. Currently, upfront radical cystectomy is the gold standard for non-metastatic SCC of the bladder. However, several studies have shown that SCC of the bladder is associated with higher aggressiveness and worse survival outcomes, such as progression-free and cancer-specific survival, relative to the urothelial histological subtype. Moreover, metastatic SCC seems to poorly respond to systemic treatments and/or radiotherapy.SUMMARY:
This review summarizes the current knowledge and medical evidence regarding local and systematic treatment of mSCC of the bladder, including a case series of four initially locally advanced and later metastatic SCC patients of our tertiary care hospital. KEY MESSAGES Despite being the second most common variant histology of bladder cancer, current therapies for SCC do not provide satisfactory therapeutic responses.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carcinoma de Células Escamosas
/
Carcinoma de Células de Transição
Limite:
Humans
Idioma:
En
Revista:
Urol Int
Ano de publicação:
2024
Tipo de documento:
Article