Relevance of NAT2 genotype and clinical factors to risk for antituberculosis drug-induced liver injury.
Pharmacogenomics
; 25(1): 21-28, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38131213
ABSTRACT
The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI), and the relationship between ATB-DILI and NAT2 gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI. Age, history of liver disease, alcohol consumption and timing of antituberculosis (ATB) treatment were independent risk factors for ATB-DILI in the patients with tuberculosis (TB; p < 0.05). There was a significant difference in the distribution of NAT2 metabolic phenotypes between the study group and the control group (p < 0.05). The ATB drug treatment for pulmonary TB can cause a high incidence of ATB-DILI. Age, history of liver disease, alcohol consumption and timing of ATB treatment are independent risk factors for ATB-DILI in patients with TB.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Arilamina N-Acetiltransferase
/
Tuberculose
/
Doença Hepática Induzida por Substâncias e Drogas
Limite:
Humans
Idioma:
En
Revista:
Pharmacogenomics
Ano de publicação:
2024
Tipo de documento:
Article