Oral ß-Lactam Pairs for the Treatment of Mycobacterium avium Complex Pulmonary Disease.
J Infect Dis
; 230(2): e241-e246, 2024 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-38150401
ABSTRACT
Cure rates for pulmonary disease caused by the Mycobacterium avium complex (MAC) are poor. While ß-lactam are front line antibiotics against Mycobacterium abscessus pulmonary disease, they have not been used or recommended to treat MAC lung infections. Through a comprehensive screen of oral ß-lactams, we have discovered that selected pairs combining either a penem/carbapenem or penicillin with a cephalosporin are strongly bactericidal at clinically achieved concentrations. These dual ß-lactam combinations include tebipenem and sulopenem, both in phase 3, and Food and Drug Administration-approved amoxicillin and cefuroxime. They could therefore immediately enter clinical trials or clinical practice.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo Mycobacterium avium
/
Infecção por Mycobacterium avium-intracellulare
/
Beta-Lactamas
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2024
Tipo de documento:
Article