Iodobenzene-Catalyzed Synthesis of Fully Functionalized NH-Pyrazoles and Isoxazoles from α,ß-Unsaturated Hydrazones and Oximes via 1,2-Aryl Shift.
Org Lett
; 26(1): 385-389, 2024 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-38150709
ABSTRACT
An iodine(III)-catalyzed general method for the synthesis of fully functionalized NH-pyrazoles and isoxazoles from α,ß-unsaturated hydrazones and oximes, respectively, via cyclization/1,2-aryl shift/aromatization/detosylation, has been developed. The reaction progresses through an anti-Baldwin 5-endo-trig cyclization. It gives direct access to an advanced intermediate for the preparation of valdecoxib and parecoxib, drugs used for COX-inhibition. In addition, a method for N-alkynylation of pyrazoles has also been developed in the presence of TIPS-EBX.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2024
Tipo de documento:
Article