Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder.
Natl Sci Rev
; 10(11): nwad312, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-38152386
ABSTRACT
Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric disorder that affects â¼2%-3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors (SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter (GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor (human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Natl Sci Rev
Ano de publicação:
2023
Tipo de documento:
Article