A Biotinylated Glycosylphosphatidylinositol (GPI) as the Universal Platform To Access GPI-Anchored Protein Analogues.

Yan, Xin; Guo, Jiatong; Kundu, Sayan; Guo, Zhongwu

Yan, Xin; Guo, Jiatong; Kundu, Sayan; Guo, Zhongwu.

Afiliação

Yan X; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Guo J; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Kundu S; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Guo Z; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.

J Org Chem ; 89(2): 1345-1352, 2024 01 19.

Article em En | MEDLINE | ID: mdl-38153341

ABSTRACT

ABSTRACT

A glycosylphosphatidylinositol (GPI) derivative with biotin linked to its mannose III 6-O-position was prepared by a convergent strategy. This biotinylated GPI was demonstrated to bind avidinated proteins readily through biotin-avidin interaction and, therefore, can serve as a universal platform to access various biologically significant GPI-anchored protein analogues.

Assuntos

Biotina; Glicosilfosfatidilinositóis; Glicosilfosfatidilinositóis/metabolismo; Proteínas Ligadas por GPI

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biotina / Glicosilfosfatidilinositóis Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article

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