Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses.
Environ Int
; 183: 108399, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38157606
ABSTRACT
Phthalates are widely used as plasticizer and associated with various health issues. Recently, non-phthalate plasticizers are replacing phthalates; however, the exposure to these substances and the risk in Japan is unclear. In this study, we assessed the concentrations of phthalates, non-phthalate plasticizers, and phthalate degradation products in house dust and determined their respective exposure risks via oral and dermal routes. Twelve phthalates, seven non-phthalate plasticizers, and two degradation products were determined in the house dust obtained from 100 Japanese homes. The median concentration of di(2-ethylhexyl) phthalate (DEHP), accounting for 85 % of the total concentration of phthalates and non-phthalate plasticizers detected in this study, was 2.1 × 103 µg/g of dust. Apart from DEHP, diisononyl phthalate (DINP) and di(2-ethylhexyl) terephthalate (DEHT) were the most abundant in the house dust, accounting for 6.2 % (median 1.7 × 102 µg/g of dust) and 6.1 % (median 1.7 × 102 µg/g of dust) of the total concentrations, respectively. DEHP and DEHT concentrations in house dust were higher in apartment and small houses (floor area ≤30 m2 or 31-60 m2 for DEHP and 31-60 m2 for DEHT) than in detached and large houses (floor area ≥121 m2). Conversely, di-n-butyl phthalate (DnBP) concentrations were significantly higher in detached and large houses (floor area ≥121 m2) than in apartment and small houses (floor area ≤30 m2). The total hazard quotient (HQ), using the maximum concentration in house dust, revealed that oral and dermal exposure to house dust was 1.3 × 10-6-0.11 for adults (all substances) and 1.6 × 10-5-2.2 × 10-2 for preschool children (except for DnBP and DEHP), suggesting no risk. The HQs for DnBP and DEHP exposure via house dust for preschool children using the maximum values were 0.46 and 1.2, and 6.0 × 10-3 and 0.18 using the median values, indicating that risk of DEHP exposure should be exhaustively determined by considering other exposure routes that were not evaluated in this study, such as diet.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Ftálicos
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2,4-Dinitrofenol
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Dietilexilftalato
Limite:
Adult
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Child, preschool
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Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environ Int
Ano de publicação:
2024
Tipo de documento:
Article