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Novel halogenated flame retardants in Canadian human milk from the MIREC study (2008-2011).
Rawn, Dorothea F K; Corrigan, Catherine; Ménard, Cathie; Sun, Wing-Fung; Breton, François; Arbuckle, Tye E.
Afiliação
  • Rawn DFK; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada. Electronic address: thea.rawn@hc-sc.gc.ca.
  • Corrigan C; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada.
  • Ménard C; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada.
  • Sun WF; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada.
  • Breton F; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada; Generic Drugs Division, Bureau of Pharmaceutical Science
  • Arbuckle TE; Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave, Ottawa, ON, K1A 0K9, Canada.
Chemosphere ; 350: 141065, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38159732
ABSTRACT
Novel halogenated flame retardants (NHFRs) have been developed to replace those brominated flame retardants that have been restricted due to their persistence, bioaccumulation potential and toxicity, therefore, it is important to determine whether these replacement products are present at detectable concentrations in Canadians. NHFRs were measured in human milk samples (n = 541) collected from across Canada between 2008 and 2011, which is the first pan-Canadian dataset for these chemicals in human milk. Among the 15 measured NHFRs and eight methoxy-polybrominated diphenyl ethers (MeO-PBDEs), nine NHFRs and two MeO-PBDEs (6-MeO-PBDE 47 and 2-MeO-PBDE 68) were detected at a frequency of more than 9%. Despite benzene, 1,1'-(1,2-ethanediyl)bis [2,3,4,5,6-pentabromo-]/decabromodiphenylethane [DBDPE] being detected less frequently than the other observed NHFRs, its relative contribution to the sum of nine NHFRs was important when it was present. The maximum ΣNHFR concentration in Canadian human milk was 6930 pg g-1 lipid while the maximum ΣMeO-PBDEs was 1600 pg g-1 lipid. While most NHFR concentrations were significantly correlated with each other, no relationships between maternal age, parity or pre-pregnancy BMI were identified with ΣNHFR concentrations in the milk. In contrast, maternal age was significantly correlated with ΣMeO-PBDE concentrations (r = 0.237, p < 0.001). ΣNHFR concentrations were similarly not related to maternal education, although ΣMeO-PBDE concentrations were found to be higher in milk from women who had graduated from trade schools relative to the other education levels considered. NHFR detection frequency and concentrations observed in the Canadian human milk seem to align well with Europe.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Retardadores de Chama / População Norte-Americana / Leite Humano Limite: Female / Humans País/Região como assunto: America do norte Idioma: En Revista: Chemosphere Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Retardadores de Chama / População Norte-Americana / Leite Humano Limite: Female / Humans País/Região como assunto: America do norte Idioma: En Revista: Chemosphere Ano de publicação: 2024 Tipo de documento: Article