Blood group antigens: synthesis of Ss antigenic peptides related to human glycophorin B.

ABSTRACT

The human Ss blood group antigens are located on glycophorin B, a minor human erythrocyte membrane glycoprotein. The structural difference in Ss antigens is determined by a Met/Thr polymorphism at position 29. This report describes the first synthesis of the two peptides carrying the Ss specificities, SS Asn-Gly-Glu-Met-Gly-Gln-Leu-Val and ss Asn-Gly-Glu-Thr-Gly-Gln-Leu-Val.