Your browser doesn't support javascript.
loading
The human Y and inactive X chromosomes similarly modulate autosomal gene expression.
San Roman, Adrianna K; Skaletsky, Helen; Godfrey, Alexander K; Bokil, Neha V; Teitz, Levi; Singh, Isani; Blanton, Laura V; Bellott, Daniel W; Pyntikova, Tatyana; Lange, Julian; Koutseva, Natalia; Hughes, Jennifer F; Brown, Laura; Phou, Sidaly; Buscetta, Ashley; Kruszka, Paul; Banks, Nicole; Dutra, Amalia; Pak, Evgenia; Lasutschinkow, Patricia C; Keen, Colleen; Davis, Shanlee M; Lin, Angela E; Tartaglia, Nicole R; Samango-Sprouse, Carole; Muenke, Maximilian; Page, David C.
Afiliação
  • San Roman AK; Whitehead Institute, Cambridge, MA 02142, USA.
  • Skaletsky H; Whitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA.
  • Godfrey AK; Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Bokil NV; Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Teitz L; Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Singh I; Whitehead Institute, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Blanton LV; Whitehead Institute, Cambridge, MA 02142, USA.
  • Bellott DW; Whitehead Institute, Cambridge, MA 02142, USA.
  • Pyntikova T; Whitehead Institute, Cambridge, MA 02142, USA.
  • Lange J; Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Koutseva N; Whitehead Institute, Cambridge, MA 02142, USA.
  • Hughes JF; Whitehead Institute, Cambridge, MA 02142, USA.
  • Brown L; Whitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA.
  • Phou S; Whitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA.
  • Buscetta A; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kruszka P; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Banks N; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
  • Dutra A; Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Pak E; Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Lasutschinkow PC; Focus Foundation, Davidsonville, MD 21035, USA.
  • Keen C; Focus Foundation, Davidsonville, MD 21035, USA.
  • Davis SM; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Lin AE; Medical Genetics, Massachusetts General for Children, Boston, MA 02114, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Tartaglia NR; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Developmental Pediatrics, eXtraOrdinarY Kids Program, Children's Hospital Colorado, Aurora, CO 80011, USA.
  • Samango-Sprouse C; Focus Foundation, Davidsonville, MD 21035, USA; Department of Pediatrics, George Washington University, Washington, DC 20052, USA; Department of Human and Molecular Genetics, Florida International University, Miami, FL 33199, USA.
  • Muenke M; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Page DC; Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA. Electronic address: dcpage@wi.mit.edu.
Cell Genom ; 4(1): 100462, 2024 Jan 10.
Article em En | MEDLINE | ID: mdl-38190107
ABSTRACT
Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46th chromosome is a Y; in females it is an "inactive" X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects. Studying sex chromosome structural anomalies, promoters of Xi- and Y-responsive genes, and CRISPR inhibition, we traced part of this shared effect to homologous transcription factors-ZFX and ZFY-encoded by Chr X and Y. This demonstrates sex-shared mechanisms by which Xi and Y modulate autosomal expression. Combined with earlier analyses of sex-linked gene expression, our studies show that 21% of all genes expressed in lymphoblastoid cells or fibroblasts change expression significantly in response to Xi or Y chromosomes.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Cromossomo Y Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Cell Genom Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Cromossomo Y Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Cell Genom Ano de publicação: 2024 Tipo de documento: Article