Lactate administration improves laboratory parameters in murine models of iron overload.

Liu, Wei; Wu, Yue; Wei, Huaiqing; Ma, Juan; Feng, Wenya; Yang, Qiuyuan; Zhang, Shuping; Ganz, Tomas; Liu, Sijin

Liu, Wei; Wu, Yue; Wei, Huaiqing; Ma, Juan; Feng, Wenya; Yang, Qiuyuan; Zhang, Shuping; Ganz, Tomas; Liu, Sijin.

Afiliação

Liu W; Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Wu Y; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Wei H; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Ma J; University of Chinese Academy of Sciences, Beijing, China.
Feng W; Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Yang Q; Biomedical Sciences College and Shandong Medicinal Biotechnology Centre, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Zhang S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Ganz T; University of Chinese Academy of Sciences, Beijing, China.
Liu S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Blood ; 143(11): 1045-1049, 2024 Mar 14.

Article em En | MEDLINE | ID: mdl-38194678

ABSTRACT

ABSTRACT

ABSTRACT Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in ß-thalassemic mice.

Assuntos

Sobrecarga de Ferro; Talassemia beta; Camundongos; Animais; Hepcidinas; Modelos Animais de Doenças; Ácido Láctico; Talassemia beta/tratamento farmacológico; Sobrecarga de Ferro/tratamento farmacológico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia beta / Sobrecarga de Ferro Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article

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