Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease.
JACC Basic Transl Sci
; 8(12): 1489-1499, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38205343
ABSTRACT
There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of CHD. We developed CHDBioPRS, combining BioPRS with PRS of CHD in the UK Biobank and tested it on FinnGen. We found that BioPRS was clearly predictive of CHD and that CHDBioPRS improved the standard CHD PRS. The largest effect was observed with early onset cases in FinnGen, with HRs above 2 per standard deviation of CHDBioPRS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
JACC Basic Transl Sci
Ano de publicação:
2023
Tipo de documento:
Article