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Evaluation of three inactive vaccines against Veronaea botryosa infection in white sturgeon (Acipenser transmontanus).
McDonald, Sienna; Yazdi, Zeinab; Camus, Alvin; Soto, Esteban.
Afiliação
  • McDonald S; University of California, School of Veterinary Medicine, Department of Medicine and Epidemiology, Davis, CA, 95616, USA.
  • Yazdi Z; University of California, School of Veterinary Medicine, Department of Medicine and Epidemiology, Davis, CA, 95616, USA.
  • Camus A; University of Georgia, College of Veterinary Medicine, Department of Pathology, Athens, GA, 30602, USA.
  • Soto E; University of California, School of Veterinary Medicine, Department of Medicine and Epidemiology, Davis, CA, 95616, USA. Electronic address: sotomartinez@ucdavis.edu.
Fish Shellfish Immunol ; 145: 109368, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38211704
ABSTRACT
Veronaea botryosa is the etiological agent of a systemic phaeohyphomycosis known as "fluid belly" in white sturgeon (Acipenser transmontanus). Fluid belly is a critical disease affecting sturgeon aquaculture and the caviar industry for which there are no commercially available vaccines or approved antifungal treatments to manage outbreaks. The primary aim of this study was to investigate the effect of a V. botryosa [conidia], a V. botryosa [mold], and a Saccharomyces cerevisiae [yeast] formalin-killed vaccine on sturgeon immune responses to fungal challenge. Immunization consisted of an initial intracoelomic injection with one of the three treatment preparations, followed by a vaccine booster four weeks later by the same route and dose. Experimental challenge by intramuscular injection with a virulent V. botryosa conidia suspension followed after another four weeks. Non-challenged control fish received injections of PBS. The inactivated vaccines proved safe for white sturgeon fingerlings. Sturgeon immunized with either V. botryosa [mold] or S. cerevisiae [yeast] exhibited a significantly different pro-inflammatory response upon challenge with V. botryosa compared to non-immunized fish. Challenged fish developed clinical signs similar to those reported during natural outbreaks of fluid belly. Positive control treatments (those not immunized but challenged with V. botryosa) experienced the highest mortality; however, survival curves were similar amongst all treatments (p < 0.05). Furthermore, the S. cerevisiae [yeast] vaccine resulted in comparatively lower fungal persistence and fewer lesions following histological analysis. Further efforts evaluating the potential of Saccharomyces spp. as a vaccine candidate against fluid belly are warranted.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Ascomicetos / Saccharomyces cerevisiae Limite: Animals Idioma: En Revista: Fish Shellfish Immunol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Ascomicetos / Saccharomyces cerevisiae Limite: Animals Idioma: En Revista: Fish Shellfish Immunol Ano de publicação: 2024 Tipo de documento: Article