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[Research progress on anti-inflammatory effects of plant-derived cannabinoid type 2 receptor modulators].
Lian, Chen-Xia; Hu, Si-Jing; Zhang, Qiao-Yan; Zhao, Qi-Ming; Qin, Lu-Ping; Gong, Wan.
Afiliação
  • Lian CX; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
  • Hu SJ; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
  • Zhang QY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
  • Zhao QM; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
  • Qin LP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
  • Gong W; Fuyang Research Institute, Zhejiang Chinese Medical University Hangzhou 311422, China School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
Zhongguo Zhong Yao Za Zhi ; 48(23): 6294-6306, 2023 Dec.
Article em Zh | MEDLINE | ID: mdl-38211986
ABSTRACT
Excessive and persistent inflammatory responses are a potential pathological condition that can lead to diseases of various systems, including nervous, respiratory, digestive, circulatory, and endocrine systems. Cannabinoid type 2 receptor(CB2R) belongs to the G protein-coupled receptor family and is widely distributed in immune cells, peripheral tissues, and the central nervous system. It plays a role in inflammatory responses under various pathological conditions. The down-regulation of CB2R activity is an important marker of inflammation and and CB2R modulators have been shown to have anti-inflammatory effects. This study explored the relationship between CB2R and inflammatory responses, delved into its regulatory mechanisms in inflammatory diseases, and summarized the research progress on CB2R modulators from plants other than cannabis, including plant extracts and monomeric compounds, in exerting anti-inflammatory effects. The aim is to provide new insights into the prevention and treatment of inflammatory diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Moduladores de Receptores de Canabinoides Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Moduladores de Receptores de Canabinoides Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Ano de publicação: 2023 Tipo de documento: Article