CDs-ICG@BSA nanoparticles for excellent phototherapy and in situ bioimaging.
Talanta
; 271: 125661, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38219322
ABSTRACT
For the diagnosis and treatment of cancer, a great challenge is the fabrication of straightforward, non-toxic, multifunctional green nanomaterials. In this study, carbon quantum dots self-assembled with indocyanine green dye at bovine serum albumin for phototherapy and in situ bioimaging are produced by a flexible hydrothermal method. We find that the synthesized nanoparticles have high tumor photothermal therapeutic activity when exposed to 808 nm light, with a photothermal conversion efficiency up to 61 %. The phototoxicity study revealed the excellent phototherapy of the nanoparticles mainly arises from photothermal therapeutic effect other than photodynamic therapy effect. Simultaneously, it allows biological imaging in the visible and near-infrared ranges because of the significant absorption at 365 nm and 840 nm. The current work offers a simple, environmentally friendly, and reasonable method for developing photothermal drugs with a high photothermal conversion efficiency in the near-infrared region, as well as good biosafety for multifunctional nanomaterials for bioimaging tumor diagnosis and direct phototherapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
15_ODS3_global_health_risks
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Pontos Quânticos
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Nanopartículas
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Talanta
Ano de publicação:
2024
Tipo de documento:
Article