Strain identity of Bordetella pertussis isolates from household members based on whole-genome sequencing.
Microbiol Immunol
; 68(3): 111-114, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38224024
ABSTRACT
We evaluated the genetic diversity of Bordetella pertussis, the causative agent of pertussis, within households by whole-genome sequencing. In pairwise comparisons of 23 isolates collected from 11 households, single-nucleotide polymorphism (SNP) analysis revealed extremely low SNP diversity (≤1 SNP) between isolate pairs no SNPs were detected in 10 households and one SNP was obtained in the remaining household. This SNP was uncommon for B. pertussis and resulted in a nonsynonymous substitution (Ala303Thr) in nicotinate phosphoribosyltransferase. We demonstrated that the same strain is transmitted between household members and that B. pertussis is genomically stable during household transmission.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bordetella pertussis
/
Coqueluche
Limite:
Humans
Idioma:
En
Revista:
Microbiol Immunol
Ano de publicação:
2024
Tipo de documento:
Article