VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.
Nat Commun
; 15(1): 583, 2024 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-38233381
ABSTRACT
In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta specification are understudied due to ethical barriers and the scarcity of embryos. Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophoblast stem cells (TSCs), offering a valuable in vitro model to study early placenta specification. Here, we demonstrate that the VGLL1 (vestigial-like family member 1), which is highly expressed during human and non-human primate TE specification in vivo but is negligibly expressed in mouse, is a critical regulator of cell fate determination and self-renewal in human TELCs and TSCs derived from naïve PSCs. Mechanistically, VGLL1 partners with the transcription factor TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibility at target gene loci through histone acetylation and acts in cooperation with GATA3 and TFAP2C. Our work is relevant to understand primate early embryogenesis and how it differs from other mammalian species.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Células-Tronco Pluripotentes
Tipo de estudo:
Prognostic_studies
Aspecto:
Ethics
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2024
Tipo de documento:
Article