Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer's Disease.
Mol Neurobiol
; 61(8): 5826-5840, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38236345
ABSTRACT
Alzheimer's disease is a neurodegenerative pathology whose pathognomonic hallmarks are increased generation of ß-amyloid (Aß) peptide, production of hyperphosphorylated (pTau), and neuroinflammation. The last is an alteration closely related to the progression of AD and although it is present in multiple neurodegenerative diseases, the pathophysiological events that characterize neuroinflammatory processes vary depending on the disease. In this article, we focus on mRNA and non-coding RNA alterations as part of the pathophysiological events characteristic of neuroinflammation in AD and the influence of these alterations on the course of the disease through interaction with multiple RNAs related to the generation of Aß, pTau, and neuroinflammation itself.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
RNA não Traduzido
/
Doença de Alzheimer
/
Doenças Neuroinflamatórias
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Neurobiol
Ano de publicação:
2024
Tipo de documento:
Article