Urinary podocyte stress marker as a prognostic indicator for diabetic kidney disease.
BMC Nephrol
; 25(1): 32, 2024 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-38267859
ABSTRACT
BACKGROUND:
Diabetic kidney diseases (DKD) is a the most common cause of end-stage kidney disease (ESKD) around the world. Previous studies suggest that urinary podocyte stress biomarker, e.g. podocinnephrin mRNA ratio, is a surrogate marker of podocyte injury in non-diabetic kidney diseases.METHOD:
We studied 118 patients with biopsy-proved DKD and 13 non-diabetic controls. Their urinary mRNA levels of nephrin, podocin, and aquaporin-2 (AQP2) were quantified. Renal events, defined as death, dialysis, or 40% reduction in glomerular filtration rate, were determined at 12 months.RESULTS:
Urinary podocinnephrin mRNA ratio of DKD was significantly higher than the control group (p = 0.0019), while urinary nephrinAQP2 or podocinAQP2 ratios were not different between groups. In DKD, urinary podocinnephrin mRNA ratio correlated with the severity of tubulointerstitial fibrosis (r = 0.254, p = 0.006). and was associated with the renal event-free survival in 12 months (unadjusted hazard ratio [HR], 1.523; 95% confidence interval [CI] 1.157-2.006; p = 0.003). After adjusting for clinical and pathological factors, urinary podocinnephrin mRNA ratio have a trend to predict renal event-free survival (adjusted HR, 1.327; 95%CI 0.980-1.797; p = 0.067), but the result did not reach statistical significance.CONCLUSION:
Urinary podocinnephrin mRNA ratio has a marginal prognostic value in biopsy-proven DKD. Further validation is required for DKD patients without kidney biopsy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus
/
Nefropatias Diabéticas
/
Podócitos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
BMC Nephrol
Ano de publicação:
2024
Tipo de documento:
Article