Your browser doesn't support javascript.
loading
Association of MiRNA and Bone Tumors: Future Therapeutic Inroads.
Al-Shibli, Rashid; AlSuleimani, Mohammed; Ahmed, Ibrahim; Lawati, Abdullah Al; Das, Srijit.
Afiliação
  • Al-Shibli R; Sultan Qaboos University Hospital, Muscat123, Oman.
  • AlSuleimani M; Sultan Qaboos University Hospital, Muscat123, Oman.
  • Ahmed I; Sultan Qaboos University Hospital, Muscat123, Oman.
  • Lawati AA; Sultan Qaboos University Hospital, Muscat123, Oman.
  • Das S; Department of Human & Clinical Anatomy, Sultan Qaboos University, Muscat123, Oman.
Curr Med Chem ; 2024 Jan 30.
Article em En | MEDLINE | ID: mdl-38299295
ABSTRACT
Small endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we discuss various bone tumors with regard to their prognosis, pathogenesis, and diagnosis. The association between miRNAs and bone tumors, such as osteosarcoma, Ewing's sarcoma, chondrosarcoma, and giant-cell tumors, is also discussed. Moreover, miRNA may play an important role in tumor proliferation, growth, and metastasis. Knowledge of the dysregulation, amplification, and deletion of miRNA can be beneficial for the treatment of various bone cancers. The miRNAs could be beneficial for prognosis, treatment, future drug design, and treatment of resistant cases of bone cancer.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Curr Med Chem Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Curr Med Chem Ano de publicação: 2024 Tipo de documento: Article