Tobacco Smoke Exposure in Early Childhood and Later Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study.
J Crohns Colitis
; 18(5): 661-670, 2024 May 31.
Article
em En
| MEDLINE
| ID: mdl-38329478
ABSTRACT
OBJECTIVES:
To examine the association between early-life smoking exposure and later risk of inflammatory bowel disease [IBD].METHODS:
We followed 115663 participants from the Norwegian Mother, Father and Child [MoBa] and All Babies in Southeast Sweden [ABIS] cohorts from birth [1997-2009] through 2021. IBD was identified through national patient registers. Validated questionnaire data defined maternal smoking during pregnancy, maternal environmental tobacco smoke [ETS] exposure during pregnancy, and child ETS exposure by ages 12 and 36 months. Cox regression was used to estimate adjusted hazard ratios [aHRs] for sex, maternal age, education level, parental IBD, and origin. Cohort-specific estimates were pooled using a random-effects model.RESULTS:
During 1 987 430 person-years of follow-up, 444 participants developed IBD [ABIS, 112; MoBa, 332]. Any vs no maternal smoking during pregnancy yielded a pooled aHR of 1.30 [95% CIâ =â 0.97-1.74] for offspring IBD. Higher level of maternal smoking during pregnancy (compared with no smoking, averageâ ≥6 cigarettes/day pooled aHRâ =â 1.60 [95% CI = 1.08-2.38]) was associated with offspring IBD, whereas a lower smoking level was not (average 1-5 cigarettes/day pooled aHRâ =â 1.09 [95% CIâ =â 0.73-1.64]). Child ETS exposure in the first year of life was associated with later IBD (any vs no ETS, pooled aHRâ =â 1.32 [95% CIâ =â 1.03-1.69]). Estimates observed for child ETS exposure by 36 months were similar but not statistically significant.CONCLUSIONS:
In this prospective Scandinavian cohort study, children exposed to higher levels of maternal smoking during pregnancy or ETS during the first year of life were at increased risk of later IBD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Poluição por Fumaça de Tabaco
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Doenças Inflamatórias Intestinais
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Child, preschool
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Female
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Humans
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Infant
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Male
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Crohns Colitis
/
J. crohns. colitis
/
Journal of Crohn's and colitis (Online)
Ano de publicação:
2024
Tipo de documento:
Article