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Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study.
Harrington, Laura B; Ehlert, Alexa N; Thacker, Evan L; Jenny, Nancy S; Lopez, Oscar; Cushman, Mary; Olson, Nels C; Fitzpatrick, Annette; Mukamal, Kenneth J; Jensen, Majken K.
Afiliação
  • Harrington LB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA. Electronic address: laura.b.harrington@kp.
  • Ehlert AN; Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA.
  • Thacker EL; Department of Public Health, Brigham Young University, Provo, UT, USA.
  • Jenny NS; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Colchester, VT, USA.
  • Lopez O; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Cushman M; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Colchester, VT, USA; Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
  • Olson NC; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Colchester, VT, USA.
  • Fitzpatrick A; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Mukamal KJ; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Jensen MK; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Thromb Res ; 235: 148-154, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38340522
ABSTRACT

INTRODUCTION:

Markers of hemostasis such as procoagulant factors and peak thrombin generation are associated with cardiovascular outcomes, but their associations with dementia risk are unclear. We aimed to evaluate prospective associations of selected procoagulant factors and peak thrombin generation with dementia risk.

METHODS:

We measured levels of 7 hemostatic factors (fibrinogen, factor VII coagulant activity [FVIIc], activated factor VII [FVIIa], factor VIIa-antithrombin [FVIIa-AT], factor XI antigen [FXI], peak thrombin generation, and platelet count) among participants in the Cardiovascular Health Study, a cohort of older adults free of dementia in 1992/1993 (n = 3185). Dementia was adjudicated and classified by DSM-IV criteria through 1998/1999. Cox proportional hazards models estimated hazard ratios (HRs) for any dementia associated with 1-standard deviation (SD) differences, adjusting for sociodemographic and clinical factors and APOE genotype. Secondary analyses separately evaluated the risk of vascular dementia, Alzheimer's disease, and mixed dementia.

RESULTS:

At baseline, participants had a median age of 73 years. Over 5.4 years of follow-up, we identified 448 dementia cases. There was no evidence of linear associations between levels of these hemostatic factors with any dementia risk (HRs per 1-SD difference ranged from 1.0 to 1.1; 95 % confidence intervals included 1.0). Results of secondary analyses by dementia subtype were similar.

CONCLUSIONS:

In this prospective study, there was no strong evidence of linear associations between levels of fibrinogen, FVIIc, FVIIa, FVIIa-AT, FXI, peak thrombin generation, or platelet count with dementia risk. Despite their associations with cardiovascular disease, higher levels of these biomarkers measured among older adults may not reflect dementia risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Demência Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Thromb Res Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Demência Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Thromb Res Ano de publicação: 2024 Tipo de documento: Article