Mediation of the association between depression and coronary heart disease by metabolic syndrome components.
Ann Epidemiol
; 92: 1-7, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38341050
ABSTRACT
BACKGROUND:
Depression is associated with incident coronary heart disease (CHD) via a pathway that may be causal, but the mechanisms underlying this association are unclear. We assessed the extent to which metabolic syndrome (MetS) and its components (i.e., elevated waist circumference, low high-density lipoprotein [HDL] cholesterol, elevated triglycerides, elevated blood pressure, and elevated fasting plasma glucose) may mediate this association.METHODS:
Data were Framingham Heart Study Research Materials obtained from the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository Information Coordinating Center. We used Cox proportional hazards regression to estimate adjusted hazard ratios (aHR) representing the total effect (aHRTE) of probable depression, measured via the Centers for Epidemiological Studies - Depression scale, on incident CHD over approximately 18 years. Using inverse odds ratio weighting, we decomposed this estimate into natural direct effects (aHRNDE) and natural indirect effects (aHRNIE) through potential mediators (measured approximately three years after depression).RESULTS:
Probable depression was associated with incident CHD (aHRTE=1.45, 95% confidence interval [CI] 0.93, 2.25), and elevated waist circumference partially mediated this association (aHRNDE=1.34, 95% CI 0.76-2.32; aHRNIE=1.08, 95% CI 0.63-1.91). We did not find evidence of additional mediation by additional MetS components.CONCLUSIONS:
Elevated waist circumference appears to play a role in the association between depression and CHD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença das Coronárias
/
Síndrome Metabólica
/
Hipertensão
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Epidemiol
Ano de publicação:
2024
Tipo de documento:
Article