Irreversible electroporation: Beyond the limits of tumor ablation.
Radiologia (Engl Ed)
; 66(1): 47-56, 2024.
Article
em En
| MEDLINE
| ID: mdl-38365354
ABSTRACT
Irreversible Electroporation (IRE) is a non-thermal tumor ablation technique. High-voltage electrical pulses are applied between pairs of electrodes inserted around and/or inside a tumor. The generated electric current induces the creation of nanopores in the cell membrane, triggering apoptosis. As a result, IRE can be safely used in areas near delicate vascular structures where other thermal ablation methods are contraindicated. Currently, IRE has demonstrated to be a successful ablation technique for pancreatic, renal, and liver tumors and is widely used as a focal therapeutic option for prostate cancer. The need for specific anesthetic management and accurate parallel placement of multiple electrodes entails a high level of complexity and great expertise from the interventional team is required. Nevertheless, IRE is a very promising technique with a remarkable systemic immunological capability and may impact on distant metastases (abscopal effect).
Palavras-chave
Ablation techniques; Electroporación; Electroporación irreversible; Electroporation; Immunotherapy; Inmunoterapia; Interventional; Irreversible electroporation therapy; Liver neoplasms; Medical oncology; Neoplasias hepáticas; Neoplasias pancreáticas; Neoplasias renales; Oncología; Pancreatic neoplasms; Radiology; Radiología; Radiología intervencionista; Renal neoplasm; Técnicas ablativas
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Técnicas de Ablação
/
Neoplasias Hepáticas
Limite:
Humans
/
Male
Idioma:
En
Revista:
Radiologia (Engl Ed)
Ano de publicação:
2024
Tipo de documento:
Article