Inhibition of histalog-stimulated gastric secretion by 40 749 RP, a new long-acting gastric antisecretory agent.
Drugs Exp Clin Res
; 11(10): 675-8, 1985.
Article
em En
| MEDLINE
| ID: mdl-3836854
ABSTRACT
40 749 RP, an N-methyl-2-(2-pyridyl)-2,3,4,5-tetrahydro-2-thiophene carbothioamide derivative, is already known as a potent gastric antisecretory agent in animals and in man. In order to determine its duration of action, its activity was investigated on Histalog-stimulated gastric acid secretion in 6 healthy volunteers. The efficacy of a 2 mg/kg dose, compared with that of placebo, was potent, and remained the same when the drug was ingested 6 h before stimulation instead of 1 h. The duration of action of 40 749 RP is therefore longer than 6 h.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Tiofenos
/
Betazol
/
Suco Gástrico
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Drugs Exp Clin Res
Ano de publicação:
1985
Tipo de documento:
Article