Endothelial dysfunction of syphilis: Pathogenesis.
J Eur Acad Dermatol Venereol
; 38(8): 1478-1490, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38376088
ABSTRACT
Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of T. pallidum. In this review, we focus on how T. pallidum establish intimate interactions with ECs, triggering endothelial dysfunction such as endothelial inflammation, abnormal repairment and damage of ECs. In addition, we summarize that migration and invasion of T. pallidum across vascular ECs may occur through two pathways. These two mechanisms of transendothelial migration are paracellular and cholesterol-dependent, respectively. Herein, clarifying the relationship between T. pallidum and endothelial dysfunction is of great significance to provide novel strategies for diagnosis and prevention of syphilis, and has a great potential prospect of clinical application.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Treponema pallidum
/
Endotélio Vascular
/
Sífilis
Limite:
Humans
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Ano de publicação:
2024
Tipo de documento:
Article