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Melanocortin-1 receptor (MC1R): a review for dermatologists.
Guida, Stefania; Puig, Susana; DI Resta, Chiara; Sallustio, Fabio; Mangano, Eleonora; Stabile, Giorgio; Longo, Caterina; Pellacani, Giovanni; Guida, Gabriella; Rongioletti, Franco.
Afiliação
  • Guida S; Dermatology Clinic, IRCCS San Raffaele Hospital, Milan, Italy - guida.stefania@hsr.it.
  • Puig S; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy - guida.stefania@hsr.it.
  • DI Resta C; Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, Instituto de Investigaciones Biomédicas August Pi i Sunye, University of Barcelona, Barcelona, Spain.
  • Sallustio F; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Mangano E; Genomic Unit for the Diagnosis of Human Pathologies, IRCCS San Raffaele Hospital, Milan, Italy.
  • Stabile G; Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy.
  • Longo C; Institute of Biomedical Technologies (ITB), National Research Center (CNR), Segrate, Milan, Italy.
  • Pellacani G; Dermatology Clinic, IRCCS San Raffaele Hospital, Milan, Italy.
  • Guida G; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Rongioletti F; Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
Ital J Dermatol Venerol ; 159(3): 285-293, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38376504
ABSTRACT
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R, phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Receptor Tipo 1 de Melanocortina Limite: Humans Idioma: En Revista: Ital J Dermatol Venerol Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Receptor Tipo 1 de Melanocortina Limite: Humans Idioma: En Revista: Ital J Dermatol Venerol Ano de publicação: 2024 Tipo de documento: Article