Association between estrogen replacement therapy and heart failure in postmenopausal women: A systematic review and meta-analysis.
Prev Med
; 181: 107909, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38382766
ABSTRACT
BACKGROUND:
Based on past epidemiological investigations, the cardiovascular role of estrogen replacement therapy (ERT) in postmenopausal women has always been controversial. The real efficacy of ERT for heart failure (HF) among postmenopausal women remains to be further investigated. This article is based on research into European and American populations.PURPOSE:
To determine the impact of estrogen replacement therapy on HF using meta-analysis. METHODS ANDMATERIAL:
Electronic literature was searched on Web of Science, PubMed, and Embase databases to identify randomized controlled trials (RCTs) comparing the hospitalization for heart failure between ERT users and non-users among postmenopausal women. Pairs of reviewers screened eligible articles independently, extracted data, and evaluated the risk of bias. Summary relative risks were estimated for the composite endpoint of first hospitalized heart failure and admission to the hospital for heart failure.RESULTS:
A pooled study of five randomized controlled trials found that estrogen replacement therapy had no significant effect on the composite endpoint in postmenopausal women, with a relative risk of 1.02 (95% CI 0.94-1.10).CONCLUSION:
This systematic review demonstrated that estrogen replacement therapy did not significantly change the risk of first hospitalized heart failure and admission to the hospital for heart failure in postmenopausal women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia de Reposição de Estrogênios
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Pós-Menopausa
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Insuficiência Cardíaca
Limite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Prev Med
Ano de publicação:
2024
Tipo de documento:
Article