Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days' Oral Intake.
Toxics
; 12(2)2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38393216
ABSTRACT
Mechanically fibrillated cellulose nanofibers, known as fib-CNF (fiber length 500 nm; diameter 45 nm), are used in composites and as a natural thickener in foods. To evaluate their safety, we conducted a 28-day study in mice with inhalation exposure at 0.2 mg/body and oral administration of 400 mg/kg/day. Inhalation exposure to fib-CNF caused transient weight loss, changes in blood cell counts, and increased lung weights. These changes were attributed to adaptive responses. The oral administration of fib-CNF for 28 days resulted in no apparent toxic effects except for a slight decrease in platelet counts. The fib-CNF administration using the protocols studied appears to be safe in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Toxics
Ano de publicação:
2024
Tipo de documento:
Article