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Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era.
Uppala, Rattapon; Sitthikarnkha, Phanthila; Faksri, Kiatichai; Kosalaraksa, Pope; Techasatian, Leelawadee; Tantawarak, Nattakarn; Nanthavongsa, Sysavanh.
Afiliação
  • Uppala R; Faculty of Medicine, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand.
  • Sitthikarnkha P; Faculty of Medicine, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand.
  • Faksri K; Faculty of Medicine, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand.
  • Kosalaraksa P; Faculty of Medicine, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand.
  • Techasatian L; Faculty of Medicine, Department of Microbiology, Khon Kaen University, Khon Kaen, Thailand.
  • Tantawarak N; Faculty of Medicine, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand.
  • Nanthavongsa S; Faculty of Medicine, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand.
PLoS One ; 19(2): e0297991, 2024.
Article em En | MEDLINE | ID: mdl-38394318
ABSTRACT

PURPOSE:

This study aimed to investigate the antibodies against SARS-CoV-2 in children hospitalized due to COVID-19 during the era of pre-Omicron and Omicron variants.

METHODS:

This was a retrospective observational study conducted at a tertiary academic medical center in Thailand between June 2021 and August 2022. We collected the data of children aged under 18-year who were hospitalized from SARS-CoV-2 infection. After hospital discharge, we scheduled clinical follow-up 60 to 90 days post-infection clinical follow-up. We measured antibodies against SARS-CoV-2 anti-spike protein receptor-binding domain in the serum during a follow-up visit and compared the mean difference of antibody levels between children infected with COVID-19 during the pre-Omicron and Omicron eras.

RESULTS:

A total of 119 children enrolled into the study. There were 58 and 61 children hospitalized due to COVID-19 during pre-Omicron and Omicron era, respectively. The median (interquartile range, IQR) of SARS-CoV-2 antibodies in all cases was 206.1 (87.9-424.1) U/mL at follow-up. Children infected during pre-Omicron had SARS-CoV-2 antibody levels at follow-up higher than children infected during Omicron era [mean difference 292.57 U/mL, 95% CI 53.85-531.28, p = 0.017). There was no difference in SARS-CoV-2 antibody levels between the children based on gender, age, co-morbidities, chest radiograph classification, or diagnosis.

CONCLUSIONS:

The antibodies response to SARS-CoV-2 infection was weaker during the Omicron era than previous variant of concern. Immunization strategies and policies should be implemented in children even if they had been previously infected.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Child / Humans Idioma: En Revista: PLoS One Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Child / Humans Idioma: En Revista: PLoS One Ano de publicação: 2024 Tipo de documento: Article