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The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles.
Chang, Ziyao; Wu, Yuhuan; Hu, Ping; Jiang, Junhuang; Quan, Guilan; Wu, Chuanbin; Pan, Xin; Huang, Zhengwei.
Afiliação
  • Chang Z; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Wu Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Hu P; College of Pharmacy, Jinan University, Guangzhou 511443, China.
  • Jiang J; College of Pharmacy, Jinan University, Guangzhou 511443, China.
  • Quan G; College of Pharmacy, Jinan University, Guangzhou 511443, China.
  • Wu C; College of Pharmacy, Jinan University, Guangzhou 511443, China.
  • Pan X; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Huang Z; College of Pharmacy, Jinan University, Guangzhou 511443, China.
Pharmaceutics ; 16(2)2024 Feb 17.
Article em En | MEDLINE | ID: mdl-38399340
ABSTRACT
Transdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter the challenge of a low transdermal absorption rate. Microneedles can overcome the stratum corneum barrier to enhance the transdermal absorption rate. Among various types of microneedles, nanoparticle-loaded dissolving microneedles (DMNs) present a unique combination of advantages, leveraging the strengths of DMNs (high payload, good mechanical properties, and easy fabrication) and nanocarriers (satisfactory solubilization capacity and a controlled release profile). Consequently, they hold considerable clinical application potential in the precision medicine era. Despite this promise, no nanoparticle-loaded DMN products have been approved thus far. The lack of understanding regarding their in vivo fate represents a critical bottleneck impeding the clinical translation of relevant products. This review aims to elucidate the current research status of the in vivo fate of nanoparticle-loaded DMNs and elaborate the necessity to investigate the in vivo fate of nanoparticle-loaded DMNs from diverse aspects. Furthermore, it offers insights into potential entry points for research into the in vivo fate of nanoparticle-loaded DMNs, aiming to foster further advancements in this field.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2024 Tipo de documento: Article