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Progress of Drug Nanocrystal Self-Stabilized Pickering Emulsions: Construction, Characteristics In Vitro, and Fate In Vivo.
Zhang, Jifen; Dong, Fangming; Liu, Chuan; Nie, Jinyu; Feng, Shan; Yi, Tao.
Afiliação
  • Zhang J; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Dong F; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Liu C; Chengdu Institute of Food Inspection, Chengdu 611130, China.
  • Nie J; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Feng S; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Yi T; Faculty of Health Sciences and Sports, Macao Polytechnic University, Macau 999078, China.
Pharmaceutics ; 16(2)2024 Feb 19.
Article em En | MEDLINE | ID: mdl-38399347
ABSTRACT
A drug nanocrystal self-stabilized Pickering emulsion (DNSPE) is a novel Pickering emulsion with drug nanocrystals as the stabilizer. As a promising drug delivery system, DNSPEs have attracted increasing attention in recent years due to their high drug loading capacity and ability to reduce potential safety hazards posed by surfactants or specific solid particles. This paper comprehensively reviews the progress of research on DNSPEs, with an emphasis on the main factors influencing their construction, characteristics and measurement methods in vitro, and fate in vivo, and puts forward issues that need to be studied further. The review contributes to the advancement of DNSPE research and the promotion of their application in the field of drug delivery.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2024 Tipo de documento: Article