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Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation.
Kuroiwa, Kai; Sato, Misuzu; Narita, Hinako; Okamura, Reiko; Uesugi, Yuka; Sasaki, Yohei; Shimada, Shotaro; Watanuki, Megumi; Fujiwara, Shun; Kawaguchi, Yukiko; Arai, Nana; Yanagisawa, Kouji; Iezumi, Keiichi; Hattori, Norimichi.
Afiliação
  • Kuroiwa K; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Sato M; Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.
  • Narita H; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Okamura R; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Uesugi Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Sasaki Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Shimada S; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Watanuki M; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Fujiwara S; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Kawaguchi Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Arai N; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Yanagisawa K; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Iezumi K; Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.
  • Hattori N; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. nhattor@med.showa-u.ac.jp.
Int J Hematol ; 119(5): 583-591, 2024 May.
Article em En | MEDLINE | ID: mdl-38418747
ABSTRACT
The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3-3279C/A or FOXP3-3279A/A genotype than those with the FOXP3-3279C/C genotype [hazard ratio (HR), 2.69; 95% confidence interval (CI) 1.14-6.31; p = 0.023]. Therefore, FOXP3 at SNP rs3761548 can be a useful marker for predicting the occurrence of severe cGVHD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Homólogo / Transplante de Células-Tronco Hematopoéticas / Neoplasias Hematológicas / Polimorfismo de Nucleotídeo Único / Fatores de Transcrição Forkhead / Doença Enxerto-Hospedeiro Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Hematol Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Homólogo / Transplante de Células-Tronco Hematopoéticas / Neoplasias Hematológicas / Polimorfismo de Nucleotídeo Único / Fatores de Transcrição Forkhead / Doença Enxerto-Hospedeiro Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Hematol Ano de publicação: 2024 Tipo de documento: Article