Association between vitamin D receptor gene polymorphisms and genetic susceptibility to benign prostatic hyperplasia: A systematic review and meta-analysis.
Medicine (Baltimore)
; 103(9): e37361, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38428858
ABSTRACT
BACKGROUND:
Benign prostatic hyperplasia (BPH) is one of the global public health challenges due to the complexity of its mechanisms of occurrence. Many studies have suggested that vitamin D receptor gene polymorphisms are associated with BPH susceptibility. Still, their conflicting findings need to be analyzed in aggregate to gain a better understanding.METHODS:
We identified 10 trials involving 1539 BPH cases and 1915 controls through a systematic search of Embase using, data obtained from the Web of Science, PubMed, and China Knowledge Network databases as of December 31, 2021. A meta-analysis was performed to investigate the association between 4 constant polymorphisms of this associated vitamin D receptor gene (Fok-1, Bsm-1, Taq-1, and Apa-1) and BPH risk.RESULTS:
In the overall population analysis, a significant positive association with BPH risk was found only in the Taq-1 variant (Pâ <â .001). Of these, the pure-hybrid model (95% confidence interval [CI]â =â 1.384-3.196), the heterozygous model (95% CIâ =â 1.207-2.021), the dominant model (95% CIâ =â 1.312-2.133) and the allelic inheritance model (95% CIâ =â 1.205-1.730) showed low heterogeneity. In subtype analyses, Bsm-1 variants showed a significant association with BPH risk for both the recessive (95% CIâ =â 0.100-0.943, Pâ =â .039) and over-dominant (95% CIâ =â 1.553-3.100, Pâ =â 0) models in the Caucasian population, and for the recessive (95% CIâ =â 1.242-3.283, Pâ =â .039) and over-dominant (95% CIâ =â 0.281-0.680, Pâ =â 0) models in the Asian population. In addition, a high degree of heterogeneity was found in the subgroup analysis of the association between Fok-1 variants and BPH risk.CONCLUSION:
Overall, there is an association between vitamin D receptor polymorphisms and BPH risk. Identification of BPH susceptibility by vitamin D receptor gene polymorphisms has potential.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiperplasia Prostática
/
Receptores de Calcitriol
Limite:
Humans
/
Male
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2024
Tipo de documento:
Article