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Association Between Atrial Fibrillation Symptoms and Clinical Outcomes: A Prospective Multicenter Registry Study.
Lee, Sang Jun; Park, Junbeom; Park, Jin-Kyu; Kang, Ki-Woon; Shim, Jaemin; Choi, Eue-Keun; Kim, Jun; Kim, Jin-Bae; Lee, Young Soo; Park, Hyung Wook; Joung, Boyoung.
Afiliação
  • Lee SJ; Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park J; Department of Cardiology, School of Medicine, Ewha Woman's University, Seoul, Republic of Korea.
  • Park JK; Department of Cardiology, Hanyang University Seoul Hospital, Seoul, Republic of Korea.
  • Kang KW; Division of Cardiology, ChungAng University Hospital, Seoul, Republic of Korea.
  • Shim J; Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea.
  • Choi EK; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
  • Kim J; Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Kim JB; Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of Korea.
  • Lee YS; Division of Cardiology, Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu, Republic of Korea.
  • Park HW; Department of Cardiology, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Republic of Korea.
  • Joung B; Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: cby6908@yuhs.ac.
Am J Cardiol ; 217: 68-76, 2024 04 15.
Article em En | MEDLINE | ID: mdl-38432331
ABSTRACT
The presence of symptoms plays an important role in determining whether to focus on rhythm control or rate control when treating atrial fibrillation (AF). Previous comparative studies on the clinical outcomes of symptomatic and asymptomatic AF have yielded inconsistent results, and a link between AF symptoms and left atrial (LA) remodeling is not established. Patients selected from the COmparison study of Drugs for symptom control and complication prEvention of AF (CODE-AF) registry, which is a prospective, multicenter study consisting of patients with non-valvular AF, were grouped into 2 groups symptomatic and asymptomatic. The primary outcome was a composite of the following cardiovascular

outcomes:

all-cause death, ischemic stroke, transient ischemic attack, systemic embolism, myocardial infarction, and heart failure hospitalization. Of 10,210 patients with AF, 4,327 (42%) had symptomatic AF. The asymptomatic group had an older mean age, more men, and more patients with hypertension and diabetes mellitus than the symptomatic group. The asymptomatic group had a larger left atrium (LA) diameter (43.6 vs 42.2 mm, p <0.001) than the symptomatic group. During a median follow-up of 32.9 (29.5 to 36.4) months, the asymptomatic and symptomatic groups showed similar incidences of the primary outcome (1.44 vs 1.45 per 100 person-years; log-rank, p = 0.8). In conclusion, the absence of AF symptoms is associated with increased LA. However, symptomatic and asymptomatic patients with AF have a similar risk of cardiovascular outcomes. This suggests that beneficial treatment for AF may be considered regardless of whether patients have symptomatic or asymptomatic AF.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Acidente Vascular Cerebral / Embolia Limite: Humans / Male Idioma: En Revista: Am J Cardiol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Acidente Vascular Cerebral / Embolia Limite: Humans / Male Idioma: En Revista: Am J Cardiol Ano de publicação: 2024 Tipo de documento: Article