Evaluation of copeptin in children after stimulation with clonidine or L-Dopa.
J Pediatr Endocrinol Metab
; 37(5): 441-444, 2024 May 27.
Article
em En
| MEDLINE
| ID: mdl-38462927
ABSTRACT
OBJECTIVES:
Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children.METHODS:
Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120â¯min after administration of clonidine or L-Dopa.RESULTS:
Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5â¯% in the clonidine arm (p=0.60) or 8â¯% in the L-Dopa arm (p=0.75) respectively.CONCLUSIONS:
Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicopeptídeos
/
Levodopa
/
Clonidina
Limite:
Adolescent
/
Child
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Child, preschool
/
Female
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Humans
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Ano de publicação:
2024
Tipo de documento:
Article