Prediction of prognosis in oral squamous cell carcinoma using infrared microspectroscopy.
Cancer Med
; 13(5): e7094, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38468595
ABSTRACT
BACKGROUND:
Estimation of prognosis of oral squamous cell carcinoma (OSCC) is inaccurate prior to surgery, only being effected following subsequent pathological analysis of the primary tumour and excised lymph nodes. Consequently, a proportion of patients are overtreated, with an increase in morbidity, or undertreated, with inadequate margins and risk of recurrence. We hypothesise that it is possible to accurately characterise clinical outcomes from infrared spectra arising from diagnostic biopsies. In this first step, we correlate survival with IR spectra derived from the primary tumour.METHODS:
Infrared spectra were collected from tumour tissue from 29 patients with OSCC and subject to classification modelling.RESULTS:
The model had a median AUROC of 0.89 with regard to prognosis, a median specificity of 0.83, and a hazard ratio of 6.29 in univariate Cox proportional hazard modelling.CONCLUSION:
The data suggest that FTIR spectra may be a useful early biomarker of prognosis in OSCC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Neoplasias de Cabeça e Pescoço
Limite:
Humans
Idioma:
En
Revista:
Cancer Med
Ano de publicação:
2024
Tipo de documento:
Article