Toward a more holistic approach to the study of exposures and child outcomes.
Epigenomics
; 2024 Mar 14.
Article
em En
| MEDLINE
| ID: mdl-38482639
ABSTRACT
Aim:
The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes.Methods:
Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data.Results:
Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function.Conclusion:
Findings demonstrate how an exposome-based approach can be utilized to understand relationships between internal (e.g., DNA methylation) and external (e.g., prenatal risk) exposures and long-term developmental outcomes in preterm children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2024
Tipo de documento:
Article