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Toward a more holistic approach to the study of exposures and child outcomes.
Lester, Barry M; Camerota, Marie; Everson, Todd M; Shuster, Coral L; Marsit, Carmen J.
Afiliação
  • Lester BM; Department of Pediatrics, Brown Alpert Medical School & Women & Infants Hospital, Providence, RI 02905, USA.
  • Camerota M; Brown Center for the Study of Children at Risk, Brown Alpert Medical School & Women & Infants Hospital, Providence, RI 02905, USA.
  • Everson TM; Department of Psychiatry & Human Behavior, Brown Alpert Medical School, Providence, RI 02905, USA.
  • Shuster CL; Brown Center for the Study of Children at Risk, Brown Alpert Medical School & Women & Infants Hospital, Providence, RI 02905, USA.
  • Marsit CJ; Department of Psychiatry & Human Behavior, Brown Alpert Medical School, Providence, RI 02905, USA.
Epigenomics ; 2024 Mar 14.
Article em En | MEDLINE | ID: mdl-38482639
ABSTRACT

Aim:

The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes.

Methods:

Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data.

Results:

Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function.

Conclusion:

Findings demonstrate how an exposome-based approach can be utilized to understand relationships between internal (e.g., DNA methylation) and external (e.g., prenatal risk) exposures and long-term developmental outcomes in preterm children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Epigenomics Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Epigenomics Ano de publicação: 2024 Tipo de documento: Article