Preoperative serum selenium predicts acute kidney injury after adult cardiac surgery.
BMC Cardiovasc Disord
; 24(1): 159, 2024 Mar 14.
Article
em En
| MEDLINE
| ID: mdl-38486133
ABSTRACT
BACKGROUND:
The relationship between serum selenium (Se) and acute kidney injury after adult cardiac surgery (CSA-AKI) remains controversial. This study aimed to investigate the association of preoperative Se level with incident CSA-AKI. METHOD ANDRESULTS:
A retrospective cohort study was conducted on patients who underwent cardiac surgery. The primary outcome was incident CSA-AKI. Multivariable logistic regression models and natural cubic splines were used to estimate the association of Se levels and primary outcome. A total of 453 patient with a mean age of 62.97 years were included. Among all patients, 159 (35.1%) incident cases of CSA-AKI were identified. The level of preoperative Se concentration in patients with CSA-AKI was significant lower than that in patients without CSA-AKI. The higher preoperative Se level was significantly associated with decreased risk of CSA-AKI (adjusted OR 0.91, 95% CI 0.87-0.99). Dose-response relationship curve revealed a nearly L-shape correlation between serum Se selenium levels and incident CSA-AKI.CONCLUSION:
Our study suggested that a higher level of serum Se was significantly associated with lower risk of CSA-AKI. Further prospective studies are needed to clarify the causal relationship between serum Se level and incident CSA-AKI.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Injúria Renal Aguda
/
Procedimentos Cirúrgicos Cardíacos
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
BMC Cardiovasc Disord
Ano de publicação:
2024
Tipo de documento:
Article