The liver as a cytokine factory working on mRNA blueprints for cancer immunotherapy.

Berraondo, Pedro; Gomis, Gabriel; Melero, Ignacio

Berraondo, Pedro; Gomis, Gabriel; Melero, Ignacio.

Afiliação

Berraondo P; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA) and Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Gomis G; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA) and Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Melero I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA) and Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Departments of Immunology and Oncology, Clínica Universidad de Navarra, Pamplona, Spain; Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: imelero@unav.es.

Cancer Cell ; 42(4): 502-504, 2024 Apr 08.

Article em En | MEDLINE | ID: mdl-38490214

ABSTRACT

ABSTRACT

mRNA has the potential to encode both vaccines and immunomodulatory proteins for cancer immunotherapy. In this issue, Beck et al. report on lipopolyplexed mRNAs encoding albumin-stabilized interleukin-2 to transduce liver cells. These mRNAs attain antitumor efficacy on subcutaneous mouse tumors even if malignant cells lack major histocompatibility complex class I (MHC class I) expression.

Assuntos

Citocinas; Neoplasias; Animais; Camundongos; RNA Mensageiro/genética; Neoplasias/genética; Neoplasias/terapia; Fígado; Imunoterapia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Neoplasias Limite: Animals Idioma: En Revista: Cancer Cell Ano de publicação: 2024 Tipo de documento: Article

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